The laboratory is interested in the relationships between structure and function of biologically important macromolecules.  The lab utilizes the disciplines of X-ray crystallography and Cryo-EM to determine the atomic resolution structures of the macromolecules and higher-ordered complexes. The molecule’s atomic resolution structure provides tremendous insight into understanding how the macromolecule (protein) functions. Hypotheses on structure – function relationships can be drawn from the structures, which are investigated using biochemistry, cell biology, and other biophysical techniques. Currently, the laboratory is focusing on three important biochemical pathways; RNA editing by ADARs, sulfate activation, and sialic acid.